Endocrine Abstracts

Introduction: subacute thyroiditis (SAT) is an inflammatory disease of the thyroid gland causing transient thyrotoxicosis, characterized by neck pain and symptoms of thyroid hormones excess. Viral infections are considered the main trigger of SAT. SAT has also been described after vaccination against H1 N1 vaccine, seasonal influenza virus vaccine, Human Papillomavirus vaccine, and hepatitis B vaccination; more recently, a rising number of cases of SAT following SARS-CoV-2 vac...

Background: In the last decades mini-invasive techniques have been proposed to reduce costs and complications of emithyroidectomy and thyroidectomy, both for benign nodular goiter and thyroid microcarcinoma, and image-guided laser and radiofrequency ablation are the most used.Purpose: To investigate short and long-term efficacy of image-guided laser and radiofrequency ablation as therapy options for benign nodular goiter.Methods: F...

Background: Alström Syndrome (ALMS, OMIM 203800) is an ultra-rare disease caused by autosomal recessive mutations of the ALMS1 gene (2p13). ALMS is characterized by double sensory impairment and systemic comorbidities, including hyperandrogenism in female patients. Fertility issue and conception have not been systematically studied.Case: This case report describes the pregnancy and birth by an ALMS patient with mild phenotype, characterized...

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary autosomal dominant tumor syndrome caused by inactivating mutations of the tumor suppressor gene MEN1 which encodes the protein menin. It is characterized by the occurrence of tumors involving two or more endocrine glands, primarily parathyroid, entero-pancreatic, and anterior pituitary, as well as non-endocrine neoplasms. Glucagonomas occur in fewer than 3% of patients with MEN1, causing hyper...

Background: Sirolimus is an immunosuppressive drug with anti-fibrotic and anti-proliferative activities. In vitro, sirolimus inhibits differentiation of orbital fibroblasts from patients with Graves’ orbitopathy (GO), suggesting a possible use in clinical practice.Methods: We performed a retrospective investigation aimed at evaluating the effects of sirolimus as a second-line treatment for moderate-to-severe, active GO, compared with methyl...

Background: In recent years, increasing cases of congenital hypothyroidism (CH) with in situ thyroid gland (GIS) are identified. Outcome of children affected from CH with normally sited thyroid of normal size is still unknown. The objective of our study is to describe the natural history of this specific form of CH.Methods: We retrospectively evaluated clinical, biochemical and instrumental data of 89 patients with diagnosis of CH and GIS, refer...

Objective: Tablet levothyroxine (L-T4) is the common used therapy for hypothyroidism. In order to assess a good compliance to the therapy, treated patients are monitored with the execution of annual thyroid hormonal test. The stability of TSH levels in hypothyroid patients (with no malabsorption issues), treated with liquid L-T4, compared to that of the patients treated with tablet L-T4, remained a poorly understood topic. This study has the purpose to deepen this issue.<p...

Objective: An enhancement of the response rate has been recently showed in patients with Graves’ ophthalmopathy (GO) treated with corticosteroids and mycophenolic acid. In GO, retro-orbital cells showed a cytokine-induced secretion of Th1 and Th2 chemokines. Since no data are present in literature about the effect of corticosteroids and mycophenolic acid on the chemokines secretion in GO orbital cells, we aim to deepen out this topic.Methods: We est...

The endogenous thyroid hormone derivative 3-iodothyronamine (T1AM), and its metabolite 3-iodothyroacetic acid (TA1) are known to stimulate learning and induce hyperalgesia in mice. Recently, it has been demonstrated that exogenous T1AM is able to rescue synaptic impairment after transient ischemia in the entorhinal cortex (EC), a brain area crucially involved in learning and memory, and early affected during Alzheimer’s disease. However, i...

Objectives: Image-guided thermal-ablation (LTA; RFA) are well established therapy options in selected BTN. PMWT is a mini-invasive technique recently applied in thyroid disease; aim of this work is investigate its effectiveness as treatment in BTN.Methods: From May 2021, 45 patients (30 F, 15 M, Aged 37-90, Mean 55,8) with BTN symptomatic/in growing, refusing/non eligible to surgery were enrolled. Inclusion criteria: nodule diameter ≥ 2 cm, mainly ...